Motor unit number estimation. Analysis was made using GraphPad Prism 5.

Motor unit number estimation. As major clinical therapeutic trials in motor neuron disease continue to appear, the need for a clear quantitative method of following motor unit physiology in the living subject grows ever Sep 3, 2014 · Introduction: Numerous methods for motor unit number estimation (MUNE) have been developed. In a cross-sectional study of ALS subjects, we made comparisons between motor unit number estimation (MUNE) values and several measures reflecting Jul 3, 2021 · MScanFit is a new motor unit number estimation (MUNE) method. Fundamental concepts and methods of motor unit number estimation All current techniques for counting motor units rely on the same basic premise. Further, th … One possible measure would be an estimate of the number of surviving motor units. Motor unit number estimation (MUNE) is a unique electrophysiologic test used to estimate the number of surviving motor units in a muscle or group of muscles. Loss of motor units is also a major factor in development of sarcopenia (Gilmore et al. A s … Jan 1, 2021 · Abstract Motor unit number estimation (MUNE) methods have been found to be better suited than any other electrophysiological test to study the degree and time course of lower motor unit loss. Objective: To evaluate a modification of standard incremental MUNE in a multicenter natural history study of subjects with ALS. The examined muscles included first dorsal interosseous . Abstract valuate the number of motor axons connected to a muscle. Jul 23, 2023 · Background: MScanFit is a new motor unit number estimation (MUNE) technique applied in motor neuron diseases and polyneuropathies to assess clinical progression and underlying disease pathology. MUNE measures the actual number of axons that innervate a muscle, rapidly and reliably. Of particular interest is its use as an endpoint measure in clinical trials for these diseases. Electrodes with diferent recording areas were employed to record CMAP scan data in existing studies. All other neurophysiologic techniques are influenced by collateral reinnervation and provide only a qualitative estimate of motor unit loss. Muscle Velocity Recovery Cycles (MVRCs) provide information about muscle membrane properties and can reveal disease-related changes. MUNE is an electrophysiological technique that estimates the number of functioning motor units in a given muscle or group of muscles (6, 7). A quantitative study of surviving motor units was made possible by the advent of motor unit number estimation techniques, which all rely on the ratio between the supramaximal CMAP amplitude and the average surface-recorded motor unit potential (SMUP) amplitude, and to which the motor unit number index (MUNIX) belongs. Feb 1, 2007 · Motor unit number estimation (MUNE) is a unique electrophysiologic technique that can provide a numeric estimate of the number of axons innervating a muscle or group of muscles. e. A metric of influence was used to determine if different methods had clear peaks of use over the Jan 1, 2004 · This chapter describes the various motor unit number estimation (MUNE) methods and their application to patients with amyotrophic lateral sclerosis (ALS). It may quantify axonal loss in any disease involving injury or degeneration of ventral horn cells or motor axons. Differences of opinion remain among MUNE investigators as to which method is best; however, statistical and MPS MUNE are currently the most widely used. The original technique was a modification of the compound muscle action potential (CMAP) recording technique that employed a gradual increase of stimulation to obtain submaximal increments. The objective of this article is to summarize and compare the major methods and the available data regardin Dec 2, 2016 · Motor-unit number estimation MUNE analysis was performed in all participants using the multipoint stimulation method. Introduction: MScanFit is a model-based algorithm for motor unit number estimation (MUNE) from compound muscle action potential (CMAP) scan data. The various MUNE techniques and their common technical issues will be reviewed, and potential clinical and research applications emphasized. However, the efect of electrode recording area on MScanFit MUNE Mar 31, 2021 · Motor unit number estimate (MUNE) is a more reliable, physiologic technique than the CMAP amplitude in quantifying the numbers of MUs innervating an individual muscle and measure disease progression [4]. This may be because an ideal method has not been developed yet. Low MUNE counts provide evidence of LMN degeneration, but a single MUNE study does not determine if this loss is ongoing, recent or remote in MUNE is a unique neurophysiologic tool because it can quantitatively estimate the number of motor neurons innervating a muscle or group of muscles. This review aims to give an overview of the strengths and limitations of Aug 1, 2018 · Estimation of the number of motor units (MUNE) in specific muscles is important to monitor outcome in progressive neurogenic disorders, with potential… Aug 1, 2018 · Estimation of the number of motor units (MUNE) in specific muscles is important to monitor outcome in progressive neurogenic disorders, with potential… In motor neuron diseases, such as amyotrophic lateral sclerosis and spinal muscular atrophy, motor neurons progressively degenerate, resulting in a reduced number of motor units. The first technique was first described in 1971, and since then different techniques have been developed to address specific methodologic issues. Mar 28, 2003 · Statistical motor unit number estimation (MUNE) is one of several experimental techniques used to estimate the number of lower motor neurons innervating a given muscle. Numer … Like other methods for motor unit number estimation (MUNE), compound muscle action potential (CMAP) scan MUNE (MScan) is a non-invasive electrophysiologic method to estimate the number of functioning motor units in a muscle. It is a clinically applicable tool because of its quick and automatic implementation. Motor unit number estimation (MUNE) is a technique that uses electromyography to estimate the number of motor units in a muscle. Abstract Objective: To evaluate how the motor unit number index (MUNIX) is related to high-density motor unit number estimation (HD-MUNE) in healthy controls and patients with amyotrophic lateral sclerosis (ALS). This method can serve as a surrogate marker for functional disability but also gives information about motor unit characteristics [11, 12]. The program fits the CMAP scan using an increasing staircase function. Since its introduction 30 years ago, MUNE techniques have increasingly been refined and applied to a wide variety of neuromuscular disorders. Its use and advantages compared to other MUNE methods have mainly been proven in patients with amyotrophic lateral sclerosis (ALS) [4]. The purpose of this study was to compare MU properties among 3 groups categorized as either pre-sarcopenic (n = 7), sarcopenic (n = 7), or severely sarcopenic (n = 5), all with similarly aged subjects (75-82 years). 運動単位数推定法 (英 Motor Unit Number Estimation, MUNE)は、 筋電図 から 運動単位 の数を推定する技法である。 Standard electromyography (EMG) and nerve conduction studies provide valuable data regarding disease type, severity, and localization at a given point in time but are less effective in measuring longitudinal motor neuron loss once a disease process has been identified. Motor unit number estimation (MUNE) in 45 control subjects (35 young Jun 1, 2001 · Motor unit number estimation (MUNE) was introduced in 1971 as a way of providing an objective and meaningful estimate of axon loss in diseases affecting the motor system. All MUNE techniques rely on assumptions that must be Jun 2, 2006 · A number of different methods of motor unit number estimation (MUNE) have been developed since the original incremental method of McComas et al. Few studies have explored its utility in 5q spinal muscular atrophy (SMA5q) patients, assessing only the abductor pollicis brevis (APB) muscle. Aug 31, 2016 · Decomposition and quantitative analysis of clinical electromyographic Motor unit number estimation by decomposition-enhanced spike-triggered averaging: control data, test–retest reliability, and contractile level effects Assessment of variability in the shape of the motor unit action potential, the “jiggle,” at consecutive discharges Compound muscle action potential (CMAP) scan provides a detailed stimulus-response curve for examination of neuromuscular disease. Motor unit number estimation (MUNE) is a type of electrophysiological technique that measures the approximate number of lower motor neurons (LMNs) innervating a single muscle or a small group of muscles. The K-means clustering convolution kernel compensation algorithm was employed to detect the single motor unit potentials Introduction: Numerous methods for motor unit number estimation (MUNE) have been developed. The objective of the study is to develop a novel CMAP scan analysis to extract motor unit number estimation (MUNE) and other physiological or diagnostic information. In a clinical setting, reinnervation type changes in the EMG similar to that occurring in neuronopathies or axon … Jan 1, 2007 · Motor unit number estimation (MUNE) is a unique electrophysiologic technique that can provide a numeric estimate of the number of axons innervating a muscle or group of muscles. High-density surface EMG, us… Mar 15, 2006 · Motor unit number estimation (MUNE) consists of a number of different methods that evaluate the last unmeasured variable in nerve disease. Methods: Using decomposition-enhanced quantitative Mar 15, 2006 · Because of the effects of collateral sprouting and reinnervation, techniques to measure the number of motor units supplying a muscle have been more difficult to develop. The objective of this article is to summarize and compare the major methods and the available data regarding their reproducibility, validity, appli-cation, refinement, and utility. We investigated the availability of motor unit number estimation (MUNE) as a quantitative method to assess the severity and clinical progression of amyotrophic lateral sclerosis (ALS). Motor unit number estimation (MUNE) is an electrophysiologic method to estimate the number of lower motor neurons innervating a group of muscles supplied by a nerve, 10 and is well suited to assess motor neuron loss in SMA. Jun 15, 2011 · Motor unit number estimation (MUNE) is a potentially attractive tool. The objective of this article is to summarize and compare the major methods and the available data regarding their reproducibility, validity, application, refinement, and utility. MUNE methods previously employed in Mar 11, 2008 · To investigate the number of motor units from the tibialis anterior (TA) muscle in normal subject and its change after SCI. This article Feb 16, 2021 · Motor unit number estimation (MUNE) methods have been found to be better suited than any other electrophysiological test to study the degree and time course of lower motor unit loss. Abstract Objective: Motor Unit Number Estimation (MUNE) methods, such as the recently developed MScanFit MUNE (MScan), may be valuable in tracking motor unit loss in ALS. Most have been based on the calculation of the mean size of motor unit potentials. Jul 19, 2011 · Motor unit number estimation (MUNE) is a potentially attractive tool. Sep 1, 2016 · To advance the motor unit number estimation (MUNE) technique using high density surface electromyography (EMG) decomposition. Recent studies using MScanFit have shown early motor involvement and neurogenic reorganization in May 24, 2018 · Abstract Estimation of the number of motor units (MUNE) in specific muscles is important to monitor outcome in progressive neurogenic disorders, with potential application in clinical trials. , 2017). First, a maximal response is generated from the muscle being stimulated, using an electrical stimulus to the nerve innervating that muscle. The number of motor units in a muscle cannot be measured precisely, although various methods can be used to obtain a motor unit number estimate (MUNE). Recent studies using MScanFit have shown early motor involvement and neurogenic reorganization in Aug 15, 2023 · MScanFit is a new motor unit number estimation method, which has been mainly investigated in motor neuron diseases and polyneuropathies [[8], [9], [10]]. Motor-unit-number-estimation-by-StairFit This is a free and open source Matlab program for StairFit motor unit number estimation (MUNE) based on a compound muscle action potential (CMAP) scan. We prospectively studied 64 patients with motor neuron disease (amyotrophic lateral sclerosis (ALS), familial ALS (fALS), progressive muscular atrophy (PMA) and primary lateral sclerosis (PLS)) using multiple point stimulation motor unit number estimation (MUNE), transcranial magnetic stimulation (T … Motor unit number estimation (MUNE) can be a valuable tool for assessing ALS (3 - 5). Mar 14, 2019 · Abstract Various neurological diseases involving motor neurons damage lead to a decrease in the number of functioning motor units (MUs). MScanFit variables indicate that compound muscle action potential amplitudes are maintained by collateral sprouting. Motor unit number estimation (MUNE) is a potentially attractive tool. , motor unit number index (MUNIX), and motor unit number estimation (MUNE) methods, the impact on the overall muscle composition via electrical impedance myography, and the complementary role of neuromuscular imaging in ALS. Therefore, it is an indirect measure of motor neuron loss, rather than a means of primary pathology. A motor unit consists of one alpha motor neuron and all the muscle fibres it innervates. Over the last 30 years, different methods of MUNE have been proposed, with each having specific strengths and limitations. Our aim is to develop a method of MUNE that overcomes these objections. Analysis was made using GraphPad Prism 5. However it is derived, the average single motor unit response is divided into the maximum response to yield a number reflecting the number of units that made up the response. Introduction MScanFit is a motor unit number estimation (MUNE) method based on compound muscle action potential (CMAP) scan and a model simulation of the responses (Bostock, 2016; Jacobsen et al. Estimation of the number of motor units (MUNE) in specific muscles is important to monitor outcome in progressive neurogenic disorders, with potential application in clinical trials. 16, 17 By stimulating the nerve at several sites, this technique yields data from motor units with different morphologies. Sep 25, 2015 · Motor unit number estimation (MUNE) was originally described by McComas et al. , 2006, Bromberg, 2007), and aids the assessment of the efficacy of potential therapy Jan 31, 2025 · Finally, an exploratory analysis of the correlation between other MScanFit variables (the number of motor units that make up the top 50% of the cumulative amplitude (N50), the median unit amplitude (A50 (%)), largest unit (%) and peak amplitude) and the primary and secondary outcomes was performed. The first Motor Unit Number Estimation (MUNE) is a technique that uses electromyography to estimate the number of motor units in a muscle. These measures can provide insight into the normal Feb 21, 2021 · Motor unit number estimation (MUNE) methods, motor unit number index (MUNIX) in particular, could be a promising tool for evaluating progression in ALS. The field was reviewed in this journal in 2001, and this update covers Nov 10, 2015 · 2 Department of Neurology, Hannover Medical School, Hannover, Germany Motor unit number estimation (MUNE) is an electrophysiological technique to assess the number of motor units innervating a single muscle or muscle group of interest. Jan 1, 2004 · The way this estimation is made varies from technique to technique, and has been the source of most of the theoretical objections raised. These increments were summed and averaged to determine an estimated size of a single motor unit Motor unit number estimation (MUNE) is a technique that uses electromyography to estimate the number of motor units in a muscle. So far, its value in myopathies, especially myotonic dystrophies (MD), has not been investigated. Compound muscle action potential (CMAP) and motor unit number estimation (MUNE) are electrophysiological techniques that can be used to monitor the functional status of a motor unit pool in vivo. , 2018a). Feb 1, 2016 · Motor unit number estimation as a complementary test to routine electromyography in the diagnosis of amyotrophic lateral sclerosis Author links open overlay panel Malgorzata Gawel a , Ewa Zalewska b , Marta Lipowska a , Anna Kostera-Pruszczyk a , Elzbieta Szmidt-Salkowska a , Anna Kaminska a Show more Add to Mendeley In neurogenic disorders, the hallmark of muscle weakness is the loss of the motor unit, either at the anterior horn cell or motor axon. The original method was published in 1971, but secondary and tertiary waves of research using alternative methods occurred in the early 2000s and a decade later. MUNE is based on determining the size of an average surface-recorded single motor unit (S-MUP) and dividing that value into the maximal compound muscle action potential. MUNE methods previously employed in multicenter trials exhibited excessive variability and were prone to artifact. Jun 1, 2024 · This includes techniques that investigate the number of surviving motor neurons in limb muscles, i. It is used most frequently to monitor lower motor neuron loss in amyotrophic lateral sclerosis and spinal muscle atrophy. Abstract Motor unit number estimation (MUNE) techniques have evolved substantially over the past decade and have been applied, with increasing frequency, to the study of amyotrophic lateral sclerosis (ALS). Motor unit number estimation (MUNE) provides a reliable estimate of the number of functional motor units present in such diseases. Objective: The study aims to characterize the motor unit (MU) loss in spastic biceps brachii muscle (BBM) of chronic stroke survivors before and after botulinum The objective was to use bibliometric analysis to create an infographic of motor unit number estimation methods over the past 50 years. Motor unit number estimation (MUNE) was developed primarily to fill this niche. Accurate estimation of the number of intact MUs plays significant role in evaluating motor neuron death. First described in 1971, interest in MUNE has To advance the motor unit number estimation (MUNE) technique using high density surface electromyography (EMG) decomposition. Motor unit number estimation (MUNE) consists of a number of different methods that evaluate the last unmeasured variable in nerve disease. Therefore, electrophysiological techniques for MU number 1. MUNE techniques, [4] are all based on surface electromyography (EMG) measurements. Despite over 30 years of motor unit number estimation (MUNE), all proposed methods have been met with practical and theoretical objections. As a result, estimating the degree of actual motor neuron loss has remained elusive for motor neuron diseases such as amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA). However, MUNE methods have not yet been implemented in clinics and research. As there is no gold standard to compare the MUNE techniques against, we have developed a model of the relevant neuromuscular physiology and Simply put, the number of motor units in a muscle could be estimated by measuring the response when all motor axons were activated simultaneously, the maximum compound muscle action potential (CMAP), then dividing by an estimate of the average response of a single motor unit. First described in 1971, interest in MUNE has Introduction: Loss of motor units (MUs) and alterations in MU properties are major factors in development of sarcopenia. Patients with SMA show loss of motor units in distal muscles. This study was undertaken to test the applicability of MScan to the anterior tibial muscle It is unclear how comparable motor unit number estimates (MUNEs) are when derived from a non-invasive technique involving repetitive peripheral nerve … MUNE results, which suggested reduced motor unit numbers in stroke patients, in conjunction with the normal EMG features in these same muscles has given rise to different interpretations. Jan 1, 2008 · To present a motor unit number estimation (MUNE) technique that resolves alternation by means of high-density surface EMG. Prospective analyses suggest that milder affected adult patients with SMA preferentially benefit from nusinersen treatmen … Aug 1, 2019 · Motor Unit Number Estimation (MUNE) methods, such as the recently developed MScanFit MUNE (MScan), may be valuable in tracking motor unit loss in ALS. A computer model of the motor unit number estimation procedure was developed to evaluate the sampling error associated with estimates of the number of motor units in muscles. Standard electromyography (EMG) and nerve conduction studies provide valuable data regarding disease type, severity, and localization at a given point in time but are less effective in measuring longitudinal motor neuron loss once a disease process has been identified. over three decades ago 1. All are fairly reproducible an Sep 6, 2016 · As a result, estimating the degree of actual motor neuron loss has remained elusive for motor neuron diseases such as amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA). Apr 1, 2020 · Motor unit number estimation (MUNE) is a continuing challenge for clinical neurologists. Jul 1, 2005 · Motor unit number estimation (MUNE) is an electrodiagnostic procedure used to evaluate the number of motor axons connected to a muscle. All MUNE techniques rely on assumptions that must be fulfilled to produce a valid estimate. In motor neuron diseases, such as amyotrophic lateral sclerosis and spinal muscular atrophy, motor neurons progressively degenerate, resulting in a reduced number of motor units. The development of electromyography and nerve conduction studies as routine tools for clinical assessment is linked to the application of these studies to patients with motor neuron disorders. (1971). MUNE is an important tool for the assessment of neuropathies and neuronopat … Apr 27, 2023 · Introduction Motor neuron loss is the primary pathologic feature of amyotrophic lateral sclerosis (ALS). 0. Quantitative analysis of MUs by methods of routine electromyography is usually not possible. An estimate of the number of surviving motor units (MUs) represents a direct measure of the Aug 15, 2023 · MScanFit is a new motor unit number estimation method, which has been mainly investigated in motor neuron diseases and polyneuropathies [[8], [9], [10]]. 2021), Christian Schneider and colleagues at the University Hospital of Cologne and Research Center Jülich used motor unit number estimation (MUNE) and MScanFit software to examine the organization and short-term changes of motor units Apr 8, 2005 · Abstract Motor unit number estimation (MUNE) is an electrodiagnostic procedure used to evaluate the number of motor axons connected to a muscle. The K-means clustering co… Jan 1, 2004 · Motor unit number estimation (MUNE) is a unique clinical neurophysiologic technique that provides quantitative information on the number of motor units innervating a muscle and on the size of individual motor units. Dec 8, 2024 · Motor Unit Number Estimation (MUNE) is a technique that uses electromyography to estimate the number of motor units in a muscle. Motor unit number estimation (MUNE) is the most direct measure of the number of motor units contributing to a muscle contraction. Aug 1, 2008 · Motor unit number estimation (MUNE) is a unique electrophysiologic test used to estimate the number of surviving motor units in a muscle or group of muscles. MUNE is an important Abstract Introduction/aims: MScanFit MUNE (MScanFit) is a novel tool to derive motor unit number estimates (MUNEs) from compound muscle action potential (CMAP) scans. Aug 6, 2021 · Motor unit estimation assessment (photo courtesy of Dr Christian Schneider) In a recent study published in the European Journal of Neurology (Schneider et al. Motor unit number estimation (MUNE) is defined as an electrophysiologic technique that provides a numeric estimate of the number of axons innervating a muscle or group of muscles. Improved outcome measures are necessary to reduce sample size and increase power in amyotrophic lateral sclerosis (ALS) clinical trials. Abstract Pathologic progression in amyotrophic lateral sclerosis (ALS) results from motor neuron death, while the clinical expression also reflects the compensatory effects of collateral reinnervation consequent to lower motor neuron loss. The 143 ALS patients were evaluated by statistical MUNE and the revised amyotrophic lateral sclerosis functional ra … Jan 17, 2023 · The objective of this study was to estimate the number of motor units in 5 muscles from healthy individuals using the MScanFit program based on compound muscle action potential (CMAP) scan recordings. Feb 11, 2022 · Introduction The motor unit is the basic organizational and functional element for neuromuscular control. Introduction: Numerous methods for motor unit number estimation (MUNE) have been developed. Since its introduction, the method has been used to estimate motor unit number in both upper and lower limb muscles. ABSTRACT: Introduction: Numerous methods for motor unit number estimation (MUNE) have been developed. [1] A motor unit consists of one alpha motor neuron and all the muscle fibres it innervates. Methods: Motor unit loss and characteristics of patients with genetically confirmed MD type 1 (n = 7 Jan 1, 2007 · Motor unit number estimation (MUNE) is a unique electrophysiologic technique that can provide a numeric estimate of the number of axons innervating a muscle or group of muscles. All MUNE techniques rely on assump ions that must be fulfilled to produce a valid estimate. Jun 7, 2018 · Like other methods for motor unit number estimation (MUNE), compound muscle action potential (CMAP) scan MUNE (MScan) is a non-invasive electrophysiologic method to estimate the number of functioning motor units in a muscle. Determination of the number of motor units (MUs) that operate a particular muscle provides important insights into the progression of various neuromuscular ailments such as amyotrophic lateral sclerosis (Shefner et al. A number Abstract Motor unit number estimation (MUNE) was introduced in 1971 as a way of providing an objective and meaningful estimate of axon loss in diseases affecting the motor system. zhr xpbxwn yxv vspv pdynkgsll wlrg gugs nejev icltx rnmuhz

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